Abstract
The importance of the Type-1 helper immune response in the development of Vitiligo (Vit), and of chemokine receptor (CXCR)3 receptor and its chemokine monokine induced by interferon (IFN)- γ(MIG) has been shown by several studies. MIG/ interferon (IFN)-γ-inducible protein 10 (IP10) /CXCR3 axis mediated T-cell recruitment into the skin in Vit is an early event in the progression of the disease. MIG and IP10 circulating levels are increased in progressive Vit. It has been suggested that MIG and CXCR3 could be novel targets of future therapeutical approaches. Other studies have suggested that measuring MIG directly in the skin might be effective in clinical trials as an early marker of treatment response. Further studies are needed to explore the use of new molecules that act as antagonists of CXCR3, or block MIG, in Vit in a clinical setting