Evaluation of Serum Endocan Levels in Endometriosis: A case-control study
V. 171 N. 6 (2020), Research article
V. 171 N. 6 (2020)

Evaluation of Serum Endocan Levels in Endometriosis: A case-control study: Evaluation of Serum Endocan Levels in Endometriosis: A case-control study

Research article
Pubblicato 2020-11-02
Onur Güralp
Carl von Ossietzky Oldenburg University, Department of Obstetrics and Gynecology, Klinikum Oldenburg, Oldenburg, Germany
Serdar Acikgöz
Istanbul Cerrahpasa University, Department of Obstetrics and Gynecology, Istanbul, Turkey
Nevin Tüten
Kanuni Sultan Suleyman Education and Research Hospital, Obstetrics and Gynecology, Atakent Mahallesi, Halkalı Altınşehir İstanbul Cd. Istanbul, Turkey
Hakan Ekmekci
stanbul Cerrahpasa University, Department of Biochemistry, Kocamustafapasa Cad. Istanbul, Turkey
Meike Schild-Suhren
Carl von Ossietzky Oldenburg University, Department of Obstetrics and Gynecology, Klinikum Oldenburg, Oldenburg, Germany
Eduard Malik
Carl von Ossietzky Oldenburg University, Department of Obstetrics and Gynecology, Klinikum Oldenburg, Oldenburg, Germany
Abdullah Tüten
Istanbul Cerrahpasa University, Department of Obstetrics and Gynecology, Istanbul, Turkey
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Parole chiave

Angiogenesis
CA125
endometrioma

Abstract

Objective
To evaluate the possible associations between serum endocan levels and endometriosis.

Study Design
A total of 60 women with histologically proven endometriosis and 40 women who underwent laparoscopy due to unexplained infertility without endometriosis were evaluated in a case-control study. Serum endocan, CA125, CA19.9, and CA15.3 levels were measured. Demographic, clinical, and laboratory parameters were compared.

Results
There was no significant difference between the groups regarding age, body-mass-index, parity, and serum CRP and WBC levels. Serum endocan (p<0.001), CA125 (p<0.001), CA19.9 (p=0.022) and CA15.3 (p=0.013) levels were significantly higher in the endometriosis group compared to the control group. The correlation analysis showed that serum endocan level was positively correlated with the stage of the disease, CRP, and WBC, but not with remaining parameters, age, BMI, dysmenorrhea score, CA125, CA19.9, and CA15.3.
Serum CA125 can predict endometriosis (Cut off=26.2 IU/mL, AUC=0.955) with a sensitivity of 89% and specificity of 88%. Serum endocan can predict endometriosis (Cut off=454 ng/mL AUC=0.749) with a 93% sensitivity and 61% specificity.

Conclusion
The serum endocan levels were significantly elevated in women with endometriosis compared to the control group. Serum endocan can predict endometriosis with a sensitivity of 93% and specificity of 61%

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