Therapeutic effect of RA223 in the management of breast cancer bone metastases
V. 170 N. 1 (2019), Commentary
V. 170 N. 1 (2019)

Therapeutic effect of RA223 in the management of breast cancer bone metastases: doi: 10.7417/CT.2019.2100

Commentary
Pubblicato 2019-01-10
R. P. Costa
Nuclear Medicine, Biomedical Department of Internal and Specialist Medicine, University of Palermo
V. Tripoli
Nuclear Medicine, Biomedical Department of Internal and Specialist Medicine, University of Palermo
A. Princiotta
Nuclear Medicine, Biomedical Department of Internal and Specialist Medicine, University of Palermo
A. Murabito
Nuclear Medicine, Biomedical Department of Internal and Specialist Medicine, University of Palermo
M. Licari
Nuclear Medicine, Biomedical Department of Internal and Specialist Medicine, University of Palermo
F. Verderame
Department of Oncology, Villa Sofia Cervello Hospital, Palermo
A. Pinto
Internal Medicine, Biomedical Department of Internal and Specialist Medicine, University of Palermo, Italy
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Parole chiave

Bone metastases
Breast cancer
Osteoblastic bone metastases
Osteolytic bone metastases
Radium 223

Abstract

Radium 223 dichloride (Ra223) is the only targeted alpha therapy able to extend survival in patients with bone metastases from prostate cancer. Mechanism of action and data currently available focused mainly on osteoblastic metastases from prostate cancer. Phase 1 and 2 trials documented a clinical efficacy also in breast cancer patients with predominately bone disease, highlighting a reduction in alkaline phosphatase and other bone biomarkers. In our institution, a patient with breast cancer affected by osteolytic metastases was treated with off-label use of Ra223. Our patient had a good treatment compliance and up to now she has not been revealed the presence of SSE or hematological complications. Our preliminary experience shows that Ra223 may play a critical role to bone metastates in patients with breast cancer.

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