Medical Cannabis in Patients with Chronic Pain: Effect on Pain Relief, Pain Disability, and Psychological aspects. A Prospective Non randomized Single Arm Clinical Trial
PDF

Parole chiave

Anxiety
Chronic Pain
Depression
Medical Cannabis
Pain Disability

Abstract

There is an increasing interest in the medical use of cannabis, particularly in the treatment of chronic pain.

Objectives
The aim is to evaluate the effects of cannabis use and the associated benefits reported by patients with various chronic pain diagnoses.

Materials and methods
A total of 338 patients with different chronic pain conditions were treated with a Cannabis Flos 19% decoction for 12 months, in addition to their pharmacological therapy. Baseline levels for pain medications, pain intensity, pain disability, anxiety and depression were recorded at 1, 3, 6 and 12 months.

Results
Pain intensity records a statistically significant reduction from Baseline to 12 months follow up (X2 61.375; P< 0,001); the improvements from Baseline to 12 months follow up are also recorded in pain disability (X2 39.423; P<0,001) and in anxiety and depression symptoms (X230.362; P<0,001; X227.786; P<0,001).

Conclusions
Our study suggest that Cannabis therapy, as an adjunct a traditional analgesic therapy, can be an efficacious tool to make more effective the management of chronic pain and its consequences on functional and psychological dimension. Further randomized, controlled trials are needed to confirm our conclusions

PDF